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5-Amino-1MQ is a cell-permeable selective small-molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). In cellular assays, NNMT inhibition prevents the methylation and depletion of nicotinamide, leading to enhanced intracellular NAD+ salvage flux and upregulation of sirtuin-1 (SIRT1) activity. Investigated in metabolic research for its role in cellular energy balance and adipocyte differentiation pathways. Purity ≥99.0% verified by HPLC and NMR. Strictly for laboratory research.

Chemical & Analytical Specifications

Compound Identifier 5-Amino-1MQ (NNMT Inhibitor & NAD+ Catalyst)
Sequence / Structure Small molecule quinolinium derivative (C10H11N2+)
Molecular Formula C10H11N2+
Molecular Weight 159.21 g/mol
CAS Number 42464-96-0
Purity Specification ≥99.0% (HPLC & Mass Spectrometry)
Supplied Format Lyophilized vial / research capsules
Research Classification Small molecule enzyme modulator / NNMT pathway inquiry

Laboratory Handling & Solvent Protocols

To preserve structural integrity and peptide purity, lyophilized materials should be maintained at -20°C in an airtight container protected from ambient moisture and light. Reconstitution should be conducted under sterile conditions using bacteriostatic water (0.9% benzyl alcohol) or sterile laboratory saline. Allow the diluent to run gently down the interior vial wall; avoid vigorous shaking or vortexing to prevent shear-induced degradation. Reconstituted aliquots must be stored at 2°C to 8°C and evaluated within 28 to 30 days.

REGULATORY COMPLIANCE NOTICE All èvelan research products are strictly synthesized and supplied for laboratory research, analytical characterization, and scientific assay evaluation only. These materials are not intended, formulated, or approved for human, clinical, veterinary, or diagnostic application. Distribution is restricted to authorized personnel who affirm adherence to relevant institutional and laboratory safety protocols.

5-Amino-1MQ (NNMT Inhibitor & NAD+ Catalyst)

$238.00

Research Pathways & Profile

5-Amino-1MQ is a cell-permeable selective small-molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). In cellular assays, NNMT inhibition prevents the methylation and depletion of nicotinamide, leading to enhanced intracellular NAD+ salvage flux and upregulation of sirtuin-1 (SIRT1) activity. Investigated in metabolic research for its role in cellular energy balance and adipocyte differentiation pathways. Purity ≥99.0% verified by HPLC and NMR. Strictly for laboratory research.

Format & Concentration: 50mg Lyophilized Vial
≥99% HPLC Analytical Standard
Synthesized in Certified Facility
Direct Express Lab Fulfillment
Analytical Specifications & Sequence

Sequence: Small molecule quinolinium derivative (C10H11N2+) | Formula: C10H11N2+ | Molecular Weight: 159.21 g/mol | CAS Number: 42464-96-0 | Purity: ≥99.0% (RP-HPLC, ESI-MS) | Sterile Lyophilized Formulation.

Handling, Solvent & Storage Guidelines

Laboratory Assay Standard. Storage: -20°C (lyophilized powder, protected from light) or 2°C to 8°C (short-term reconstituted solution). Reconstitution: Bacteriostatic water (0.9% benzyl alcohol) via sterile interior wall flow without vortexing. Strictly prohibited for human, veterinary, or clinical use.

1All peptide compounds cataloged are intended exclusively for laboratory research, biochemical assays, and analytical characterization. Strictly not for human, veterinary, diagnostic, or therapeutic administration.
2Analytical purity (≥99%) is validated via High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS). Compound integrity is dependent on adherence to cold-chain storage and inert handling protocols.
3The acquiring entity assumes sole responsibility for regulatory compliance, laboratory safety protocols, and safe handling in accordance with federal, state, and local standards. èvelan expressly disclaims liability for off-label or unapproved application.
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